2H5L
S-Adenosylhomocysteine hydrolase containing NAD and 3-deaza-D-eritadenine
Summary for 2H5L
Entry DOI | 10.2210/pdb2h5l/pdb |
Descriptor | Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (2R,3R)-4-(4-AMINO-1H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-2,3-DIHYDROXYBUTANOIC ACID, ... (4 entities in total) |
Functional Keywords | s-adenosylhomocysteine, hydrolase, inhibitor, hypocholesterolemic activity |
Biological source | Rattus norvegicus (Norway rat) |
Cellular location | Cytoplasm: P10760 |
Total number of polymer chains | 8 |
Total formula weight | 387050.90 |
Authors | Yamada, T.,Komoto, J.,Takusagawa, F. (deposition date: 2006-05-26, release date: 2007-04-10, Last modification date: 2024-02-14) |
Primary citation | Yamada, T.,Komoto, J.,Lou, K.,Ueki, A.,Hua, D.H.,Sugiyama, K.,Takata, Y.,Ogawa, H.,Takusagawa, F. Structure and function of eritadenine and its 3-deaza analogues: Potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents. Biochem.Pharm., 73:981-989, 2007 Cited by PubMed: 17214973DOI: 10.1016/j.bcp.2006.12.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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