2GV6
Crystal Structure of Matriptase with Inhibitor CJ-730
Summary for 2GV6
Entry DOI | 10.2210/pdb2gv6/pdb |
Related | 2GV7 |
Descriptor | Suppressor of tumorigenicity 14, (S)-3-(3-(4-(2-GUANIDINOETHYL)PIPERIDIN-1-YL)-2-(NAPHTHALENE-2-SULFONAMIDO)-3-OXOPROPYL)BENZIMIDAMIDE (3 entities in total) |
Functional Keywords | matriptase, inhibitor, complex structure, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type II membrane protein (Probable): Q9Y5Y6 |
Total number of polymer chains | 1 |
Total formula weight | 27013.44 |
Authors | Bode, W. (deposition date: 2006-05-02, release date: 2006-06-06, Last modification date: 2021-06-23) |
Primary citation | Steinmetzer, T.,Schweinitz, A.,Sturzebecher, A.,Donnecke, D.,Uhland, K.,Schuster, O.,Steinmetzer, P.,Muller, F.,Friedrich, R.,Than, M.E.,Bode, W.,Sturzebecher, J. Secondary Amides of Sulfonylated 3-Amidinophenylalanine. New Potent and Selective Inhibitors of Matriptase. J.Med.Chem., 49:4116-4126, 2006 Cited by PubMed: 16821772DOI: 10.1021/jm051272l PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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