2GPL
TMC-95 based biphenyl-ether macrocycles: specific proteasome inhibitors
Summary for 2GPL
Entry DOI | 10.2210/pdb2gpl/pdb |
Related | 1JD2 1RYP |
Descriptor | Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total) |
Functional Keywords | proteasomal subunit fold represents an antiparallel beta-sheet flanked by helices; ntn-hydrolase, hydrolase |
Biological source | Saccharomyces cerevisiae (baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 705527.59 |
Authors | Groll, M.,Goetz, M.,Kaiser, M.,Weyher, E.,Moroder, M. (deposition date: 2006-04-18, release date: 2006-07-11, Last modification date: 2023-08-30) |
Primary citation | Groll, M.,Goetz, M.,Kaiser, M.,Weyher, E.,Moroder, L. TMC-95-Based Inhibitor Design Provides Evidence for the Catalytic Versatility of the Proteasome. Chem.Biol., 13:607-614, 2006 Cited by PubMed: 16793518DOI: 10.1016/j.chembiol.2006.04.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.81 Å) |
Structure validation
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