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2GPL

TMC-95 based biphenyl-ether macrocycles: specific proteasome inhibitors

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, O
(A, O)
Proteasome component Y7polymer25027191.82UniProt (P23639)
Pfam (PF10584)
Pfam (PF00227)
Saccharomyces cerevisiae (baker's yeast)Macropain subunit Y7, Proteinase YSCE subunit 7, Multicatalytic endopeptidase complex subunit Y7
2B, P
(B, P)
Proteasome component Y13polymer24427050.42UniProt (P23638)
Pfam (PF10584)
Pfam (PF00227)
Saccharomyces cerevisiae (baker's yeast)Macropain subunit Y13, Proteinase YSCE subunit 13, Multicatalytic endopeptidase complex subunit Y13
3C, Q
(C, Q)
Proteasome component PRE6polymer24126903.32UniProt (P40303)
Pfam (PF10584)
Pfam (PF00227)
Saccharomyces cerevisiae (baker's yeast)Macropain subunit PRE6, Proteinase YSCE subunit PRE6, Multicatalytic endopeptidase complex subunit PRE6
4D, R
(D, R)
Proteasome component PUP2polymer24226544.82UniProt (P32379)
Pfam (PF00227)
Pfam (PF10584)
Saccharomyces cerevisiae (baker's yeast)Macropain subunit PUP2, Proteinase YSCE subunit PUP2, Multicatalytic endopeptidase complex subunit PUP2
5E, S
(E, S)
Proteasome component PRE5polymer23325502.82UniProt (P40302)
Pfam (PF10584)
Pfam (PF00227)
Saccharomyces cerevisiae (baker's yeast)Macropain subunit PRE5, Proteinase YSCE subunit PRE5, Multicatalytic endopeptidase complex subunit PRE5
6F, T
(F, T)
Proteasome component C1polymer24426892.52UniProt (P21242)
Pfam (PF10584)
Pfam (PF00227)
Saccharomyces cerevisiae (baker's yeast)Macropain subunit C1, Proteinase YSCE subunit 1, Multicatalytic endopeptidase complex subunit C1
7G, U
(G, U)
Proteasome component C7-alphapolymer24327316.02UniProt (P21243)
Pfam (PF10584)
Pfam (PF00227)
Saccharomyces cerevisiae (baker's yeast)Macropain subunit C7- alpha, Proteinase YSCE subunit 7, Multicatalytic endopeptidase complex C7, Component Y8, SCL1 suppressor protein
8H, V
(H, V)
Proteasome component PUP1polymer22223987.32UniProt (P25043)
Pfam (PF00227)
Pfam (PF12465)
Saccharomyces cerevisiae (baker's yeast)Macropain subunit PUP1, Proteinase YSCE subunit PUP1, Multicatalytic endopeptidase complex subunit PUP1
9I, W
(I, W)
Proteasome component PUP3polymer20422496.62UniProt (P25451)
Pfam (PF00227)
Saccharomyces cerevisiae (baker's yeast)Macropain subunit PUP3, Multicatalytic endopeptidase complex subunit PUP3
10J, X
(J, X)
Proteasome component C11polymer19822545.72UniProt (P22141)
Pfam (PF00227)
Saccharomyces cerevisiae (baker's yeast)Macropain subunit C11, Proteinase YSCE subunit 11, Multicatalytic endopeptidase complex subunit C11
11K, Y
(K, Y)
Proteasome component PRE2polymer21223325.22UniProt (P30656)
Pfam (PF00227)
Saccharomyces cerevisiae (baker's yeast)Macropain subunit PRE2, Proteinase YSCE subunit PRE2, Multicatalytic endopeptidase complex subunit PRE2
12L, Z
(L, Z)
Proteasome component C5polymer22224883.92UniProt (P23724)
Pfam (PF00227)
Saccharomyces cerevisiae (baker's yeast)Multicatalytic endopeptidase complex subunit C5
13AA, M
(M, 1)
Proteasome component PRE4polymer23325945.52UniProt (P30657)
Pfam (PF00227)
Saccharomyces cerevisiae (baker's yeast)Macropain subunit PRE4, Proteinase YSCE subunit PRE4, Multicatalytic endopeptidase complex subunit PRE4
14BA, N
(N, 2)
Proteasome component PRE3polymer19621517.22UniProt (P38624)
Pfam (PF00227)
Saccharomyces cerevisiae (baker's yeast)Macropain subunit PRE3, Proteinase YSCE subunit PRE3, Multicatalytic endopeptidase complex subunit PRE3
15CA, DA
(H, V)
BENZYL [12-(2-AMINO-2-OXOETHYL)-4-NITRO-10,13-DIOXO-15-[(PROPYLAMINO)CARBONYL]-2-OXA-11,14-DIAZATRICYCLO[15 .2.2.1~3,7~]DOCOSA-1(19),3(22),4,6,17,20-HEXAEN-9-YL]CARBAMATEnon-polymer660.72Chemie (BIQ)
16AB, BB, CB, DB, EA...
(W, X, Y, Z, A...)
waterwater18.01070Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains28
Total formula weight704206.2
Non-Polymers*Number of molecules2
Total formula weight1321.3
All*Total formula weight705527.6
*Water molecules are not included.

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PDB entries from 2024-11-06

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