2GH5
Crystal Structure of human Glutathione Reductase complexed with a Fluoro-Analogue of the Menadione Derivative M5
Summary for 2GH5
Entry DOI | 10.2210/pdb2gh5/pdb |
Descriptor | glutathione reductase, mitochondrial, PHOSPHATE ION, 6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID, ... (6 entities in total) |
Functional Keywords | human glutathione reductase; a fluoro-analogue of the menadione derivative m5, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: P00390 |
Total number of polymer chains | 2 |
Total formula weight | 106901.24 |
Authors | Fritz-Wolf, K.,Winzer, A.,Bauer, H.,Schirmer, H.,Davioud-Charvet, E. (deposition date: 2006-03-25, release date: 2006-09-26, Last modification date: 2023-08-30) |
Primary citation | Bauer, H.,Fritz-Wolf, K.,Winzer, A.,Little, S.,Yardley, V.,Vezin, H.,Palfey, B.,Schirmer, R.H.,Davioud-Charvet, E. A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme J.Am.Chem.Soc., 128:10784-10794, 2006 Cited by PubMed: 16910673DOI: 10.1021/ja061155v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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