2FLR

Novel 5-Azaindole Factor VIIa Inhibitors

Summary for 2FLR

• Entry DOI: 10.2210/pdb2flr/pdb
• Related: 2FLB
• Descriptor: Coagulation factor VII, Tissue factor, [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA, ... (5 entities in total)
• Functional Keywords: short hydrogen bond, 5-azaindole inhibitors, s1 site, hydrolase-blood clotting complex, hydrolase/blood clotting
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P08709 P08709; Isoform 1: Membrane ; Single-pass type I membrane protein . Isoform 2: Secreted : P13726
• Total number of polymer chains: 3
• Total formula weight: 70248.06

Authors

Riggs, J.R.,Hu, H.,Kolesnikov, A.,Tong, Z.,Leahy, E.M.,Wesson, K.E.,Shrader, W.D.,Vijaykumar, D.,Wahl, T.A.,Sprengeler, P.A.,Green, M.J.,Yu, C.,Katz, B.A.,Young, W.B. (deposition date: 2006-01-06, release date: 2007-01-23, Last modification date: 2017-10-18)

• Primary citation: Riggs, J.R.,Hu, H.,Kolesnikov, A.,Leahy, E.M.,Wesson, K.E.,Shrader, W.D.,Vijaykumar, D.,Wahl, T.A.,Tong, Z.,Sprengeler, P.A.,Green, M.J.,Yu, C.,Katz, B.A.,Sanford, E.,Nguyen, M.,Cabuslay, R.,Young, W.B.; Novel 5-azaindole factor VIIa inhibitors.; Bioorg.Med.Chem.Lett., 16:3197-3200, 2006; PubMed: 16621549; DOI: 10.1016/j.bmcl.2006.03.049

Experimental method

X-RAY DIFFRACTION (2.35 Å)