2FLM
Human transthyretin (TTR) complexed with bivalant amyloid inhibitor (6 carbon linker)
Summary for 2FLM
| Entry DOI | 10.2210/pdb2flm/pdb |
| Descriptor | Transthyretin, 4'-{6-[4-(2-CARBOXYPHENYLAMINO)-PHENOXY]-HEXYLOXY}-BIPHENYL-4-CARBOXYLIC ACID (3 entities in total) |
| Functional Keywords | ttr, amyloid, transthyretin, hormone-growth factor complex, hormone/growth factor |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted: P02766 |
| Total number of polymer chains | 2 |
| Total formula weight | 28080.31 |
| Authors | Palaninathan, S.K.,Kelly, J.W.,Sacchettini, J.C. (deposition date: 2006-01-06, release date: 2006-02-28, Last modification date: 2023-08-30) |
| Primary citation | Green, N.S.,Palaninathan, S.K.,Sacchettini, J.C.,Kelly, J.W. Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization. J.Am.Chem.Soc., 125:13404-13414, 2003 Cited by PubMed: 14583036DOI: 10.1021/ja030294z PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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