2FES
Orally active thrombin inhibitors
Summary for 2FES
| Entry DOI | 10.2210/pdb2fes/pdb |
| Related | 1O0D |
| Related PRD ID | PRD_000480 PRD_000613 |
| Descriptor | Thrombin light chain, Thrombin heavy chain, Decapeptide Hirudin Analogue, ... (5 entities in total) |
| Functional Keywords | thrombin inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) More |
| Cellular location | Secreted, extracellular space: P00734 P00734 |
| Total number of polymer chains | 3 |
| Total formula weight | 35854.95 |
| Authors | Hoeffken, H.W. (deposition date: 2005-12-16, release date: 2006-05-09, Last modification date: 2023-08-30) |
| Primary citation | Mack, H.,Baucke, D.,Hornberger, W.,Lange, U.E.W.,Seitz, W.,Hoeffken, H.W. Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety. Bioorg.Med.Chem.Lett., 16:2641-2647, 2006 Cited by PubMed: 16517159DOI: 10.1016/j.bmcl.2006.02.040 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
Download full validation report
