2FB8

Structure of the B-Raf kinase domain bound to SB-590885

Summary for 2FB8

• Entry DOI: 10.2210/pdb2fb8/pdb
• Descriptor: B-Raf proto-oncogene serine/threonine-protein kinase, (1Z)-5-(2-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-PYRIDIN-4-YL-1H-IMIDAZOL-4-YL)INDAN-1-ONE OXIME (3 entities in total)
• Functional Keywords: kinase domain, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus (By similarity): P15056
• Total number of polymer chains: 2
• Total formula weight: 64734.83

Authors

Lougheed, J.C.,Lee, J.,Chau, D.C.,Stout, T.J. (deposition date: 2005-12-08, release date: 2006-12-12, Last modification date: 2024-02-14)

• Primary citation: King, A.J.,Patrick, D.R.,Batorsky, R.S.,Ho, M.L.,Do, H.T.,Zhang, S.Y.,Kumar, R.,Rusnak, D.W.,Takle, A.K.,Wilson, D.M.,Hugger, E.,Wang, L.,Karreth, F.,Lougheed, J.C.,Lee, J.,Chau, D.,Stout, T.J.,May, E.W.,Rominger, C.M.,Schaber, M.D.,Luo, L.,Lakdawala, A.S.,Adams, J.L.,Contractor, R.G.,Smalley, K.S.,Herlyn, M.,Morrissey, M.M.,Tuveson, D.A.,Huang, P.S.; Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.; Cancer Res., 66:11100-11105, 2006; PubMed: 17145850; DOI: 10.1158/0008-5472.CAN-06-2554

Experimental method

X-RAY DIFFRACTION (2.9 Å)