2FB8
Structure of the B-Raf kinase domain bound to SB-590885
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | B-Raf proto-oncogene serine/threonine-protein kinase | polymer | 281 | 31913.9 | 2 | UniProt (P15056) Pfam (PF07714) | Homo sapiens (human) | p94, v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | C, D (A, B) | (1Z)-5-(2-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-PYRIDIN-4-YL-1H-IMIDAZOL-4-YL)INDAN-1-ONE OXIME | non-polymer | 453.5 | 2 | Chemie (215) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A, B: 445 - 723 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Gly 443 | - | cloning artifact |
| Ser 444 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63827.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 907.1 | |
| All* | Total formula weight | 64734.8 |
