2FAK

Crystal structure of Salinosporamide A in complex with the yeast 20S proteasome

Summary for 2FAK

• Entry DOI: 10.2210/pdb2fak/pdb
• Related: 1IRU 1RYP
• Descriptor: Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total)
• Functional Keywords: proteasome, ubiquitin, drug design, inhibitor, protease, hydrolase
• Biological source: Saccharomyces cerevisiae (baker's yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 28
• Total formula weight: 705882.23

Authors

Groll, M.,Potts, B.C. (deposition date: 2005-12-07, release date: 2006-04-18, Last modification date: 2023-05-31)

• Primary citation: Groll, M.,Huber, R.,Potts, B.C.; Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of beta-Lactone Ring Opening and a Mechanism for Irreversible Binding.; J.Am.Chem.Soc., 128:5136-5141, 2006; PubMed: 16608349; DOI: 10.1021/ja058320b

Experimental method

X-RAY DIFFRACTION (2.8 Å)