2F6F

The structure of the S295F mutant of human PTP1B

Summary for 2F6F

Entry DOI	10.2210/pdb2f6f/pdb
Descriptor	Tyrosine-protein phosphatase, non-receptor type 1, CHLORIDE ION, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	phosphatase, ligand binding, mutations, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains	1
Total formula weight	35396.15
Authors	Montalibet, J.,Skorey, K.,McKay, D.,Scapin, G.,Asante-Appiah, E.,Kennedy, B.P. (deposition date: 2005-11-29, release date: 2005-12-06, Last modification date: 2023-08-23)
Primary citation	Montalibet, J.,Skorey, K.,McKay, D.,Scapin, G.,Asante-Appiah, E.,Kennedy, B.P. Residues distant from the active site influence protein-tyrosine phosphatase 1B inhibitor binding. J.Biol.Chem., 281:5258-5266, 2006 Cited by PubMed: 16332678 DOI: 10.1074/jbc.M511546200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation