2F6F
The structure of the S295F mutant of human PTP1B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase, non-receptor type 1 | polymer | 302 | 35241.2 | 1 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase 1B, PTP-1B |
| 2 | B, C, D (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 3 | E, F (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | G (A) | water | water | 18.0 | 250 | Chemie (HOH) |
Sequence modifications
A: 1 - 298 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Ala -3 | - | cloning artifact |
| Leu -2 | - | cloning artifact |
| Glu -1 | - | cloning artifact |
| Phe 0 | - | cloning artifact |
| Phe 295 | Ser 295 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35241.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 155.0 | |
| All* | Total formula weight | 35396.2 |
