2F38

Crystal structure of prostaglandin F synathase containing bimatoprost

Summary for 2F38

Entry DOI	10.2210/pdb2f38/pdb
Descriptor	Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5Z)-7-{(1R,2R,3R,5S)-3,5-DIHYDROXY-2-[(1E,3S)-3-HYDROXY-5-PHENYLPENT-1-ENYL]CYCLOPENTYL}-N-ETHYLHEPT-5-ENAMIDE, ... (4 entities in total)
Functional Keywords	prostaglandin f synthase, akr1c3, pgf2alpha fromation, pgh2, bimatoprost, catalytic mechanism, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P42330
Total number of polymer chains	1
Total formula weight	38055.19
Authors	Komoto, J.,Yamada, T.,Watanabe, K.,Woodward, D.F.,Takusagawa, F. (deposition date: 2005-11-18, release date: 2006-10-31, Last modification date: 2023-08-23)
Primary citation	Komoto, J.,Yamada, T.,Watanabe, K.,Woodward, D.F.,Takusagawa, F. Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost. Biochemistry, 45:1987-1996, 2006 Cited by PubMed: 16475787 DOI: 10.1021/bi051861t PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation