2F1Y

Crystal structure of the TRAF-like domain of HAUSP/USP7 bound to a MDM2 peptide

Summary for 2F1Y

• Entry DOI: 10.2210/pdb2f1y/pdb
• Related: 2F1W 2F1X
• Descriptor: HAUSP/USP7 (2 entities in total)
• Functional Keywords: hausp, usp7, mdm2, ubp, traf_like domain, mdm2 recognition, substrate binding, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus, nucleoplasm: Q00987
• Total number of polymer chains: 1
• Total formula weight: 18555.51

Authors

Hu, M.,Gu, L.,Jeffrey, P.D.,Shi, Y. (deposition date: 2005-11-15, release date: 2006-02-07, Last modification date: 2023-08-23)

• Primary citation: Hu, M.,Gu, L.,Li, M.,Jeffrey, P.D.,Gu, W.,Shi, Y.; Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.; Plos Biol., 4:e27-e27, 2006; PubMed: 16402859; DOI: 10.1371/journal.pbio.0040027

Experimental method

X-RAY DIFFRACTION (1.7 Å)