2EAT

Crystal structure of the SR CA2+-ATPASE with bound CPA and TG

Summary for 2EAT

Entry DOI	10.2210/pdb2eat/pdb
Related	1WPG 2AGV 2EAR 2EAS 2EAU
Descriptor	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, 4ALPHA, 6BETA, 6ABETA, 7BETA, 8ALPHA(Z), 9BALPHA]]-6-(ACETYLOXY)-2,3,-3A,4,5,6,6A,7,8,9B-DECAHYDRO-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(2-METHYL-1-OXO-2-BUTENYL)OX Y]-2-OXO-4-(1-OXOBUTOXY)-AZULENO[4,5-B]FURAN-7-YL ESTER, (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE (3 entities in total)
Functional Keywords	membrane protein, p-type atpase, had fold, ca2+, ion pump, hydrolase
Biological source	Oryctolagus cuniculus (rabbit)
Cellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein: P04191
Total number of polymer chains	1
Total formula weight	110615.76
Authors	Takahashi, M.,Kondou, Y.,Toyoshima, C. (deposition date: 2007-02-02, release date: 2007-03-27, Last modification date: 2023-10-25)
Primary citation	Takahashi, M.,Kondou, Y.,Toyoshima, C. Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors Proc.Natl.Acad.Sci.Usa, 104:5800-5805, 2007 Cited by PubMed: 17389383 DOI: 10.1073/pnas.0700979104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation