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2BKS

crystal structure of Renin-PF00074777 complex

Summary for 2BKS
Entry DOI10.2210/pdb2bks/pdb
Related1AO5 1BBS 1BIL 1BIM 1E80 1E81 1E82 1EED 1HRN 1MPP 1PR7 1PR8 1QZ9 1RNE 1SMR 1UHQ 1W7L 1W7M 1W7N 2BKT 2PHV 2REN
DescriptorRenin, (6R)-6-({[1-(3-HYDROXYPROPYL)-1,7-DIHYDROQUINOLIN-7-YL]OXY}METHYL)-1-(4-{3-[(2-METHOXYBENZYL)OXY]PROPOXY}PHENYL)PIPERAZIN-2-ONE (3 entities in total)
Functional Keywordshydrolase, aspartic proteinase, aspartyl protease, glycoprotein, plasma, zymogen, polymorphism
Biological sourceHomo sapiens (Human)
Cellular locationSecreted: P00797
Total number of polymer chains2
Total formula weight75121.72
Authors
Powell, N.A.,Clay, E.H.,Holsworth, D.D.,Edmunds, J.J.,Bryant, J.W.,Ryan, J.M.,Jalaie, M.,Zhang, E. (deposition date: 2005-02-18, release date: 2006-04-05, Last modification date: 2021-07-21)
Primary citationPowell, N.A.,Clay, E.H.,Holsworth, D.D.,Bryant, J.W.,Ryan, J.M.,Jalaie, M.,Zhang, E.,Edmunds, J.J.
Equipotent Activity in Both Enantiomers of a Series of Ketopiperazine-Based Renin Inhibitors
Bioorg.Med.Chem.Lett., 15:2371-, 2005
Cited by
PubMed: 15837327
DOI: 10.1016/J.BMCL.2005.02.085
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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