2B7A
The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
Summary for 2B7A
Entry DOI | 10.2210/pdb2b7a/pdb |
Descriptor | Tyrosine-protein kinase JAK2, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE (3 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Endomembrane system ; Peripheral membrane protein : O60674 |
Total number of polymer chains | 2 |
Total formula weight | 69803.44 |
Authors | Lucet, I.S.,Fantino, E.,Styles, M.,Bamert, R.,Patel, O.,Broughton, S.E.,Walter, M.,Burns, C.J.,Treutlein, H.,Wilks, A.F.,Rossjohn, J. (deposition date: 2005-10-04, release date: 2006-01-10, Last modification date: 2024-10-16) |
Primary citation | Lucet, I.S.,Fantino, E.,Styles, M.,Bamert, R.,Patel, O.,Broughton, S.E.,Walter, M.,Burns, C.J.,Treutlein, H.,Wilks, A.F.,Rossjohn, J. The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor. Blood, 107:176-183, 2006 Cited by PubMed: 16174768DOI: 10.1182/blood-2005-06-2413 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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