2B7A

The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein kinase JAK2	polymer	293	34592.4	2	UniProt (O60674) Pfam (PF07714)	Homo sapiens (human)	Janus kinase 2, JAK-2
2	C, D (A, B)	2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE	non-polymer		309.3	2	Chemie (IZA)
3	E, F (A, B)	water	water		18.0	395	Chemie (HOH)

Sequence modifications

A, B: 840 - 1132 (UniProt: O60674)

PDB	External Database	Details
Ptr 1007	Tyr 1007	modified residue
Ptr 1008	Tyr 1008	modified residue
Gln 1129	Asn 1129	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69184.8
Non-Polymers*	Number of molecules	2
	Total formula weight	618.7
All*	Total formula weight	69803.4

*Water molecules are not included.