2B55
Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole DIN-101312
Summary for 2B55
Entry DOI | 10.2210/pdb2b55/pdb |
Related | 2B52 2B53 2B54 |
Descriptor | Cell division protein kinase 2, 2-(4-(AMINOMETHYL)PIPERIDIN-1-YL)-N-(3_CYCLOHEXYL-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)ACETAMIDE (3 entities in total) |
Functional Keywords | protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34398.02 |
Authors | Muckelbauer, J. (deposition date: 2005-09-27, release date: 2005-10-11, Last modification date: 2024-02-14) |
Primary citation | Yue, E.W.,Higley, C.A.,Dimeo, S.V.,Carini, D.J.,Nugiel, D.A.,Benware, C.,Benfield, P.A.,Cox, S.,Burton, C.R.,Grafstrom, R.H.,Sharp, D.M.,Sisk, L.M.,Boylan, J.F.,Muckelbauer, J.K.,Smallwood, A.M.,Chen, H.,Chang, C.-H.,Seitz, S.P.,Trainor, G.L. Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 3. Structure Activity Relationships at C3 J.Med.Chem., 45:5233-5248, 2002 Cited by PubMed: 12431051DOI: 10.1021/jm0201722 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report