2AV1
Crystal structure of HTLV-1 TAX peptide Bound to Human Class I MHC HLA-A2 with the E63Q and K66A mutations in the heavy chain.
Summary for 2AV1
Entry DOI | 10.2210/pdb2av1/pdb |
Related | 1DUY 1DUZ 2AV7 |
Descriptor | HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Trans-activating transcriptional regulatory peptide, ... (6 entities in total) |
Functional Keywords | tax peptide, mhc, mutated hla-a2, e63q, k66a, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01892 Secreted (By similarity): P61770 Host nucleus (By similarity): P14079 |
Total number of polymer chains | 6 |
Total formula weight | 91665.74 |
Authors | Borbulevych, O.Y.,Baker, B.M. (deposition date: 2005-08-29, release date: 2005-10-18, Last modification date: 2023-08-23) |
Primary citation | Gagnon, S.J.,Borbulevych, O.Y.,Davis-Harrison, R.L.,Baxter, T.K.,Clemens, J.R.,Armstrong, K.M.,Turner, R.V.,Damirjian, M.,Biddison, W.E.,Baker, B.M. Unraveling a Hotspot for TCR Recognition on HLA-A2: Evidence Against the Existence of Peptide-independent TCR Binding Determinants. J.Mol.Biol., 353:556-573, 2005 Cited by PubMed: 16197958DOI: 10.1016/j.jmb.2005.08.024 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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