2ANJ

Crystal Structure of the Glur2 Ligand Binding Core (S1S2J-Y450W) Mutant in Complex With the Partial Agonist Kainic Acid at 2.1 A Resolution

Summary for 2ANJ

Entry DOI	10.2210/pdb2anj/pdb
Related	1FW0 1LBB 1P1N 1XHY
Descriptor	Glutamate receptor 2, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE (3 entities in total)
Functional Keywords	ionotropic glutamate receptor, glur2 ligand-binding core, agonist complex, mutant, membrane protein
Biological source	Rattus norvegicus (Norway rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	1
Total formula weight	29457.95
Authors	Holm, M.M.,Naur, P.,Vestergaard, B.,Geballe, M.T.,Gajhede, M.,Kastrup, J.S.,Traynelis, S.F.,Egebjerg, J. (deposition date: 2005-08-11, release date: 2005-08-30, Last modification date: 2023-08-23)
Primary citation	Holm, M.M.,Naur, P.,Vestergaard, B.,Geballe, M.T.,Gajhede, M.,Kastrup, J.S.,Traynelis, S.F.,Egebjerg, J. A Binding Site Tyrosine Shapes Desensitization Kinetics and Agonist Potency at GluR2: a mutagenic, kinetic, and crystallographic study J.Biol.Chem., 280:35469-35476, 2005 Cited by PubMed: 16103115 DOI: 10.1074/jbc.M507800200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation