2ACZ

Complex II (Succinate Dehydrogenase) From E. Coli with Atpenin A5 inhibitor co-crystallized at the ubiquinone binding site

Summary for 2ACZ

Entry DOI	10.2210/pdb2acz/pdb
Related	1NEK 1NEN 2AD0
Descriptor	Succinate dehydrogenase flavoprotein subunit, HEME B/C, 3-[(2S,4S,5R)-5,6-DICHLORO-2,4-DIMETHYL-1-OXOHEXYL]-4-HYDROXY-5,6-DIMETHOXY-2(1H)-PYRIDINONE, ... (12 entities in total)
Functional Keywords	membrane protein, aerobic reparatory complex ii, sqr, succinate:ubiquinone oxidoreductase, aa5, at5, atpenin a5, sdh, succinate dehydrogenase, oxidoreductase-electron transport complex, oxidoreductase/electron transport
Biological source	Escherichia coli More
Cellular location	Cell inner membrane ; Peripheral membrane protein : P07014 Cell inner membrane; Multi-pass membrane protein: P69054
Total number of polymer chains	4
Total formula weight	122367.34
Authors	Horsefield, R.,Yankovskaya, V.,Sexton, G.,Whittingham, W.,Shiomi, K.,Omura, S.,Byrne, B.,Cecchini, G.,Iwata, S. (deposition date: 2005-07-19, release date: 2006-01-03, Last modification date: 2023-10-25)
Primary citation	Horsefield, R.,Yankovskaya, V.,Sexton, G.,Whittingham, W.,Shiomi, K.,Omura, S.,Byrne, B.,Cecchini, G.,Iwata, S. Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction. J.Biol.Chem., 281:7309-7316, 2006 Cited by PubMed: 16407191 DOI: 10.1074/jbc.M508173200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation