29TC

Cryo-EM structure of homo-hexameric hLRRC8A double mutation I2C/L402W

Summary for 29TC

Entry DOI	10.2210/pdb29tc/pdb
EMDB information	57359
Descriptor	Volume-regulated anion channel subunit LRRC8A (1 entity in total)
Functional Keywords	volume-regulated anion channel subunit lrrc8a, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	6
Total formula weight	566451.10
Authors	Bertelli, S.,Wang, L.,Klussendorf, M.,Pusch, M.,Dutzler, R.,Stauber, T. (deposition date: 2026-04-07, release date: 2026-09-09)
Primary citation	Bertelli, S.,Wang, L.,Klussendorf, M.,Pusch, M.,Dutzler, R.,Stauber, T. The intracellular subdomain of the volume regulated anion channel subunit LRRC8A is a hotspot of channel activation To Be Published, 2026 Cited by DOI: 10.1038/s41467-026-77507-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.54 Å)

Structure validation