29TA

Three viral endonucleases bound to the same inhibitor (9-hydroxy-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione derivative). (2) La Crosse virus L protein endonuclease with manganese ions.

This is a non-PDB format compatible entry.

Summary for 29TA

• Entry DOI: 10.2210/pdb29ta/pdb
• Related: 29SJ 29SL
• Descriptor: RNA-directed RNA polymerase L, MANGANESE (II) ION, 9-oxidanyl-6-[(1-phenylcyclohexyl)methyl]-2-propan-2-yl-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione, ... (5 entities in total)
• Functional Keywords: endonuclease, two-metal chelating inhibitor, rna binding protein
• Biological source: La Crosse virus
• Total number of polymer chains: 1
• Total formula weight: 22612.23

Authors

Cusack, S.,Gaudon, S.,Reguera, J. (deposition date: 2026-04-07, release date: 2026-04-15)

• Primary citation: Cusack, S.,Gaudon, S.,Reguera, J.; Three viral endonucleases bound to the same inhibitor (9-hydroxy-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione derivative).; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)