29SX

Crystal structure of carbonic anhydrase XII with 2-(benzylthio)phenyl sulfamate

This is a non-PDB format compatible entry.

Summary for 29SX

• Entry DOI: 10.2210/pdb29sx/pdb
• Descriptor: Carbonic anhydrase 12, ZINC ION, [2-(phenylmethylsulfanyl)phenyl] sulfamate, ... (5 entities in total)
• Functional Keywords: drug design, carbonic anhydrase, sulfamate, lyase-inhibitor complex, lyase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 121174.48

Authors

Paketuryte-Latve, V.,Smirnov, A.,Manakova, E.N.,Grazulis, S. (deposition date: 2026-04-07, release date: 2026-10-21)

• Primary citation: Stancaitis, L.,Liberis, M.,Baranauskiene, L.,Paketuryte-Latve, V.,Kvietkauskaite, A.,Petrauskas, V.,Manakova, E.,Smirnov, A.,Mickeviciute, A.,Juozapaitiene, V.,Gedgaudas, M.,Kojis, T.,Matuliene, J.,Grazulis, S.,Capkauskaite, E.,Matulis, D.; Structure-Affinity and Selectivity of Aryl-Sulfamates as Inhibitors of Carbonic Anhydrase IX; J.Med.Chem., 69:22993-23008, 2026; DOI: 10.1021/acs.jmedchem.6c02393

Experimental method

X-RAY DIFFRACTION (1.85 Å)