29SL

Three viral endonucleases bound to the same inhibitor (9-hydroxy-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione derivative). (1b) Influenza virus A/pH1N1 polymerase PA subunit endonuclease with manganese ions.

This is a non-PDB format compatible entry.

Summary for 29SL

• Entry DOI: 10.2210/pdb29sl/pdb
• Descriptor: Polymerase acidic protein, MANGANESE (II) ION, 9-oxidanyl-6-[(1-phenylcyclohexyl)methyl]-2-propan-2-yl-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione, ... (5 entities in total)
• Functional Keywords: viral endonuclease, two-metal chelating inhibitor, rna binding protein
• Biological source: Influenza A virus; More
• Total number of polymer chains: 2
• Total formula weight: 46929.29

Authors

Cusack, S.,Gaudon, S. (deposition date: 2026-04-02, release date: 2026-04-15)

• Primary citation: Cusack, S.,Gaudon, S.; Three viral endonucleases bound to the same inhibitor (9-hydroxy-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione derivative).; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)