29PX

Crystal structure of the staphylococcal efflux pump QacA in the outward open state bound to ethidium

Summary for 29PX

• Entry DOI: 10.2210/pdb29px/pdb
• Descriptor: Antiseptic resistance protein, ETHIDIUM, GLYCEROL, ... (7 entities in total)
• Functional Keywords: multidrug efflux pump, major facilitator superfamily, mfs, dha2 family, antimicrobial resistance, drug resistance, proton-coupled transport, drug-proton antiport, membrane protein, 14-transmembrane helix, secondary active transporter, cationic substrate efflux, ethidium bromide
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 2
• Total formula weight: 114810.61

Authors

Jodaitis, L.,Hutchin, A.,Govaerts, C. (deposition date: 2026-03-27, release date: 2026-04-22)

• Primary citation: Jodaitis, L.,Sutton, P.,Hutchin, A.,Dashtbani-Roozbehani, A.,Martens, C.,Coppieters, K.,Pardon, E.,Steyaert, J.,O'Mara, M.,Brown, M.,Govaerts, C.; Structural and dynamic insights into the staphylococcal efflux pump QacA reveal multidrug transport mechanisms and substrate specificity determinants; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.79 Å)