29OM

Crystal structure of the staphylococcal efflux pump QacA in the outward open state

Summary for 29OM

• Entry DOI: 10.2210/pdb29om/pdb
• Descriptor: Antiseptic resistance protein, (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, DODECYL-ALPHA-D-MALTOSIDE, ... (8 entities in total)
• Functional Keywords: multidrug efflux pump, major facilitator superfamily, mfs, dha2 family, antimicrobial resistance, drug resistance, proton-coupled transport, drug-proton antiport, membrane protein, 14-transmembrane helix, secondary active transporter, cationic substrate efflux
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 2
• Total formula weight: 123040.42

Authors

Jodaitis, L.,Hutchin, A.,Govaerts, C. (deposition date: 2026-03-26, release date: 2026-04-22)

• Primary citation: Jodaitis, L.,Sutton, P.,Hutchin, A.,Dashtbani-Roozbehani, A.,Martens, C.,Coppieters, K.,Pardon, E.,Steyaert, J.,O'Mara, M.,Brown, M.,Govaerts, C.; Structural and dynamic insights into the staphylococcal efflux pump QacA reveal multidrug transport mechanisms and substrate specificity determinants; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.831 Å)