29OB

Crystal structure of RORg LBD in complex with DHEA

Summary for 29OB

Entry DOI	10.2210/pdb29ob/pdb
Descriptor	Nuclear receptor ROR-gamma, 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE (2 entities in total)
Functional Keywords	nuclear receptors, inhibitor, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	28631.25
Authors	Morozov, V.,Lopez-Garcia, U.,Merk, D. (deposition date: 2026-03-25, release date: 2026-07-01, Last modification date: 2026-09-30)
Primary citation	Lopez-Garcia, U.,Sai, M.,Ge, X.,Hank, E.C.,Wein, T.,Marschner, J.A.,Morozov, V.,Merk, D. Neurosteroids Inhibit ROR gamma and Induce Major Rearrangement of Its Activation Motif Acs Chem.Biol., 21:2216-2223, 2026 Cited by DOI: 10.1021/acschembio.6c00373 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.6 Å)

Structure validation