29LT

PanDDA analysis - Crystal structure of the Ubiquitin conjugating enzyme 4 from Leishmania major (LmUbC4) in complex with Z270760338

This is a non-PDB format compatible entry.

Summary for 29LT

• Entry DOI: 10.2210/pdb29lt/pdb
• Descriptor: Ubiquitin-conjugating enzyme E2 H, IMIDAZOLE, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: ubiquitin conjugating enzyme, ligase
• Biological source: Leishmania major
• Total number of polymer chains: 2
• Total formula weight: 38757.58

Authors

Exertier, C.,Fiorillo, A.,Ilari, A. (deposition date: 2026-03-20, release date: 2026-09-23)

• Primary citation: Exertier, C.,Antonelli, L.,Liuzzi, A.,Ruffa, M.,Brufani, V.,Colotti, G.,Fiorillo, A.,Ilari, A.; UbC4 from Leishmania is a Druggable E2 Ubiquitin Conjugating Enzyme: Structural Basis and Fragment Hits for Future E2-Recruiting PROTAC Development; Acs Omega, 2026; DOI: 10.1021/acsomega.6c05158

Experimental method

X-RAY DIFFRACTION (2.18 Å)