29LM

PanDDA analysis - Crystal structure of the Ubiquitin conjugating enzyme 4 from Leishmania major (LmUbC4) in complex with Z104474512

Summary for 29LM

Entry DOI	10.2210/pdb29lm/pdb
Descriptor	Ubiquitin-conjugating enzyme E2 H, IMIDAZOLE, 1-(2-ethoxyphenyl)piperazine, ... (5 entities in total)
Functional Keywords	ubiquitin conjugating enzyme, ligase
Biological source	Leishmania major
Total number of polymer chains	2
Total formula weight	38877.55
Authors	Exertier, C.,Fiorillo, A.,Ilari, A. (deposition date: 2026-03-20, release date: 2026-09-23)
Primary citation	Exertier, C.,Antonelli, L.,Liuzzi, A.,Ruffa, M.,Brufani, V.,Colotti, G.,Fiorillo, A.,Ilari, A. UbC4 from Leishmania is a Druggable E2 Ubiquitin Conjugating Enzyme: Structural Basis and Fragment Hits for Future E2-Recruiting PROTAC Development Acs Omega, 2026 Cited by DOI: 10.1021/acsomega.6c05158 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.331 Å)

Structure validation