28MR

X-ray structure of the adduct between human serum transferrin with Fe3+ bound at the C-lobe and diruthenium tetraacetate chloride

Summary for 28MR

Entry DOI	10.2210/pdb28mr/pdb
Descriptor	Serotransferrin, FE (III) ION, MALONATE ION, ... (8 entities in total)
Functional Keywords	human transferrin, diruthenium, iron, drug delivery, protein-metal interaction, metal transport
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	75730.03
Authors	Ferraro, G.,Merlino, A. (deposition date: 2026-02-08, release date: 2026-03-11)
Primary citation	Banneville, A.S.,Ferraro, G.,D'Elia, R.,Cornaciu-Hoffmann, I.,Pica, A.,Merlino, A. Ru and Rh binding sites in the structure of human serum transferrin with Fe 3+ bound at the C-lobe. Dalton Trans, 2026 Cited by PubMed Abstract: Ru and Rh binding sites in the structure of human serum transferrin with Fe bound at the C-lobe were identified by X-ray crystallography. Several His side chains and one Met are involved in the recognition of the metal ions by the protein. PubMed: 41738634 DOI: 10.1039/d6dt00205f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.262 Å)

Structure validation