28HY

Cryo-EM structure of human TMEM45A with a bound 2-Hydroxypalmitate

Summary for 28HY

Entry DOI	10.2210/pdb28hy/pdb
EMDB information	56534
Descriptor	Transmembrane protein 45A, UNKNOWN LIGAND, (R)-2-hydroxypalmitic acid, ... (4 entities in total)
Functional Keywords	orphan transmembrane protein, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	128435.89
Authors	Grieben, M.,Inderhees, J. (deposition date: 2026-02-01, release date: 2026-10-14)
Primary citation	Grieben, M.,Inderhees, J.,Ebersberger, N. Cryo-EM structure of human TMEM45A with a bound 2-Hydroxypalmitate. J.Struct.Biol., 218:108378-108378, 2026 Cited by PubMed Abstract: The orphan transmembrane protein 45 A (TMEM45A) is highly expressed in keratinocytes as well as cancer cells under hypoxic conditions, where it contributes to metastasis and chemoresistance. The structure of human TMEM45A, determined with single-particle cryo-electron microscopy (cryo-EM) to 3.27 Å, reveals a homotetrameric assembly of seven-transmembrane-helix protomers. The first six transmembrane helices (TMHs) of each protomer assemble to form a central hydrophobic tunnel containing a 2-hydroxypalmitate. PubMed: 42800517 DOI: 10.1016/j.jsb.2026.108378 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.27 Å)

Structure validation