27WI

UBE2D2 bound with compound XY54

This is a non-PDB format compatible entry.

Summary for 27WI

• Entry DOI: 10.2210/pdb27wi/pdb
• Descriptor: Ubiquitin-conjugating enzyme E2 D2, methyl 2-(2-chloranylethanoylamino)-5-methyl-1,3-thiazole-4-carboxylate (3 entities in total)
• Functional Keywords: inhibitor, structural protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 19453.00

Authors

Huang, Y.,Liu, S.,Min, J. (deposition date: 2026-06-15, release date: 2026-10-28)

• Primary citation: Liu, S.,Zheng, T.,Wu, X.,Wang, H.,Ni, S.,Dou, Y.,Li, B.,Wang, L.,Huang, Y.,Chen, X.,Min, J.; Electrophile-First Screening Identifies Covalent Aminothiazole Scaffold Inhibitors for Ubiquitin-Conjugating Enzyme UBE2D2; J.Med.Chem., 2026; DOI: 10.1021/acs.jmedchem.6c01896

Experimental method

X-RAY DIFFRACTION (2 Å)