26QM

Cryo-EM structure of human UGCG bound to UDP-glucose and a phospholipid

Summary for 26QM

• Entry DOI: 10.2210/pdb26qm/pdb
• EMDB information: 80829
• Descriptor: Ceramide glucosyltransferase, URIDINE-5'-DIPHOSPHATE-GLUCOSE, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine (3 entities in total)
• Functional Keywords: ceramide glucosyltransferase;udp-glucose, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 46257.94

Authors

Wu, C.,Jin, S.,Xu, J.,Wang, J.J.,Guo, X.,Li, Y.,Cao, Z.,Jiang, M.,Yuan, Q.,Hu, W.,Li, C.,Xu, Y.,Wang, M.W.,Jiang, Y.,Xu, H.E. (deposition date: 2026-05-11, release date: 2026-09-02)

• Primary citation: Wu, C.,Jin, S.,Xu, J.,Wang, J.J.,Guo, X.,Li, Y.,Cao, Z.,Jiang, M.,Yuan, Q.,Hu, W.,Li, C.,Xu, Y.,Wang, M.W.,Jiang, Y.,Xu, H.E.; Primate-specific regulation of the human glycosphingolipid gatekeeper UGCG; Nature, 2026; DOI: 10.1038/s41586-026-10927-4

Experimental method

ELECTRON MICROSCOPY (3.07 Å)