26QI

Cryo-EM structure of human UGCG bound to Ibiglustat

Summary for 26QI

Entry DOI	10.2210/pdb26qi/pdb
EMDB information	80826
Descriptor	Ceramide glucosyltransferase, (1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl {2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate (2 entities in total)
Functional Keywords	ceramide glucosyltransferase; ugcg;ibiglustat, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	45289.05
Authors	Wu, C.,Jin, S.,Xu, J.,Wang, J.J.,Guo, X.,Li, Y.,Cao, Z.,Jiang, M.,Yuan, Q.,Hu, W.,Li, C.,Xu, Y.,Wang, M.W.,Jiang, Y.,Xu, H.E. (deposition date: 2026-05-11, release date: 2026-09-02)
Primary citation	Wu, C.,Jin, S.,Xu, J.,Wang, J.J.,Guo, X.,Li, Y.,Cao, Z.,Jiang, M.,Yuan, Q.,Hu, W.,Li, C.,Xu, Y.,Wang, M.W.,Jiang, Y.,Xu, H.E. Primate-specific regulation of the human glycosphingolipid gatekeeper UGCG Nature, 2026 Cited by DOI: 10.1038/s41586-026-10927-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.43 Å)

Structure validation