25YR

High-resolution crystal structure of Arp2/3 complex inhibitor Arpin

Summary for 25YR

• Entry DOI: 10.2210/pdb25yr/pdb
• Descriptor: Arpin (2 entities in total)
• Functional Keywords: arp2-3 complex inhibitor, actin cytoskeleton, homodimer, cell migration, cell invasion
• Biological source: Danio rerio (zebrafish)
• Total number of polymer chains: 2
• Total formula weight: 48422.33

Authors

Liu, L.,Zhang, X.,Zhu, Y.,Zhang, R.,Wang, M.,Ye, S. (deposition date: 2026-04-23, release date: 2026-06-10)

• Primary citation: Liu, L.,Zhang, X.,Zhu, Y.,Pu, M.,Geng, Y.,Wang, M.,Zhang, R.,Ge, S.,Ye, S.; Structural basis of arpin homodimerization reveals cooperative inhibition of the Arp2/3 complex through dual-site engagement.; Protein Cell, 2026; PubMed: 41875392; DOI: 10.1093/procel/pwag021

Experimental method

X-RAY DIFFRACTION (1.65 Å)