25XO

Cryo-EM structure of the Crimean-Congo hemorrhagic fever virus full-length L protein RdRP elongation complex (EC14b form)

Summary for 25XO

• Entry DOI: 10.2210/pdb25xo/pdb
• EMDB information: 80450
• Descriptor: RNA-directed RNA polymerase L, RNA (38-MER), RNA (5'-R(*GP*GP*AP*UP*AP*UP*AP*AP*UP*CP*AP*AP*AP*A)-3'), ... (8 entities in total)
• Functional Keywords: negative-strand rna virus, crimean-congo hemorrhagic fever virus, rna-dependent rna polymerase, elongation complex, viral protein/rna, viral protein-rna complex
• Biological source: Orthonairovirus haemorrhagiae; More
• Total number of polymer chains: 6
• Total formula weight: 489281.82

Authors

Jia, H.,Tang, B.,Gong, P. (deposition date: 2026-04-22, release date: 2026-08-05)

• Primary citation: Jia, H.,Tang, B.,Liu, S.,Wen, X.,Wu, F.,Hu, X.,Zhou, H.,Chong, T.,Lv, L.,Liu, Q.,Rao, G.,Wei, M.,Jing, X.,Cao, S.,Deng, F.,Hu, Z.,Shu, B.,Gong, R.,Wu, J.,Wang, M.,Gong, P.; RNA synthesis and substrate analog inhibition in the CCHFV polymerase; Nature, 2026; DOI: 10.1038/s41586-026-10913-w

Experimental method

ELECTRON MICROSCOPY (3.18 Å)