25XL

Cryo-EM structure of the Crimean-Congo hemorrhagic fever virus L protein (apo form)

Summary for 25XL

• Entry DOI: 10.2210/pdb25xl/pdb
• EMDB information: 80447
• Descriptor: RNA-directed RNA polymerase L, ZINC ION (3 entities in total)
• Functional Keywords: negative-strand rna virus, crimean-congo hemorrhagic fever virus, rna-dependent rna polymerase, replication, transcription, viral protein
• Biological source: Orthonairovirus haemorrhagiae
• Total number of polymer chains: 1
• Total formula weight: 453333.13

Authors

Jia, H.,Liu, S.,Gong, P. (deposition date: 2026-04-22, release date: 2026-08-05)

• Primary citation: Jia, H.,Tang, B.,Liu, S.,Wen, X.,Wu, F.,Hu, X.,Zhou, H.,Chong, T.,Lv, L.,Liu, Q.,Rao, G.,Wei, M.,Jing, X.,Cao, S.,Deng, F.,Hu, Z.,Shu, B.,Gong, R.,Wu, J.,Wang, M.,Gong, P.; RNA synthesis and substrate analog inhibition in the CCHFV polymerase; Nature, 2026; DOI: 10.1038/s41586-026-10913-w

Experimental method

ELECTRON MICROSCOPY (2.88 Å)