25II

Cryo-EM structure of human Nav1.6 in complex with Iota-Conotoxin RXIA

Summary for 25II

Entry DOI	10.2210/pdb25ii/pdb
EMDB information	80134
Descriptor	Sodium channel protein type 8 subunit alpha, CHOLESTEROL, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, ... (15 entities in total)
Functional Keywords	nav1.6, voltage gated sodium channel, cryo-em, toxin, iota-conotoxin rxia, transport protein-toxin complex, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	267087.54
Authors	Fan, X.,Huang, J.,Yan, N. (deposition date: 2026-04-06, release date: 2026-05-20)
Primary citation	Fan, X.,Jian, H.,Yang, L.,Chen, J.,Wang, H.,Huang, X.,Geng, J.,Wu, Q.,Xie, Y.,Lu, F.,Guo, Q.,Shen, Z.,Jin, X.,Yan, N. Diverse modulation mechanisms of human Nav1.6 by gating modifier neurotoxins To Be Published,
Experimental method	ELECTRON MICROSCOPY (2.5 Å)

Structure validation