25IH

Cryo-EM structure of human Nav1.6 in complex with Cn2

Summary for 25IH

Entry DOI	10.2210/pdb25ih/pdb
EMDB information	80133
Descriptor	Sodium channel protein type 8 subunit alpha, CHOLESTEROL HEMISUCCINATE, CHOLESTEROL, ... (16 entities in total)
Functional Keywords	nav1.6, voltage gated sodium channel, cryo-em, toxin, cn2, transport protein-toxin complex, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	272067.88
Authors	Fan, X.,Huang, J.,Yan, N. (deposition date: 2026-04-06, release date: 2026-05-20)
Primary citation	Fan, X.,Jian, H.,Yang, L.,Chen, J.,Wang, H.,Huang, X.,Geng, J.,Wu, Q.,Xie, Y.,Lu, F.,Guo, Q.,Shen, Z.,Jin, X.,Yan, N. Diverse modulation mechanisms of human Nav1.6 by gating modifier neurotoxins To Be Published,
Experimental method	ELECTRON MICROSCOPY (2.8 Å)

Structure validation