25HO

Cryo-EM structure of the Helicobacter pylori ferritin-I69C

Summary for 25HO

• Entry DOI: 10.2210/pdb25ho/pdb
• EMDB information: 80106
• Descriptor: Bacterial non-heme ferritin (1 entity in total)
• Functional Keywords: protein polymer, i69c, ferritin, nanoparticle, structural protein
• Biological source: Helicobacter pylori
• Total number of polymer chains: 24
• Total formula weight: 483397.63

Authors

Wang, N.,Liu, Y.,Shan, J.,Rao, H.,Ma, X.,Li, Y. (deposition date: 2026-04-03, release date: 2026-07-08)

Primary citation

Liu, Y.,Rao, H.,Wang, N.,Liu, X.,Chen, T.,Zhang, B.,Lai, J.,Shan, J.,Xiao, S.,Peng, H.,Zhu, Y.,Liang, T.,Liu, S.,Hu, M.,Xie, L.,Qiu, G.,Li, X.,Li, Y.,Ma, X.
Rational design of an optimized ferritin nanoparticle vaccine targeting both SARS-CoV-2 and MERS-CoV.
J Nanobiotechnology, 2026

PubMed Abstract: Coronaviruses including SARS-CoV-2 and MERS-CoV remain threats to global health. Ferritin nanoparticle-based vaccines are promising platforms for coronaviral multivalent antigen display. However, their development is often constrained by limited stability and homogeneity, which hinders scale-up manufacturing and long-term storage.

PubMed: 42363226
DOI: 10.1186/s12951-026-04738-y

Experimental method

ELECTRON MICROSCOPY (2.2 Å)