25GF

Cryo-EM structure of the human KPTN-ITFG2-C12orf66-SZT2(2189-3432) complex

Summary for 25GF

• Entry DOI: 10.2210/pdb25gf/pdb
• EMDB information: 80082
• Descriptor: KICSTOR complex protein kaptin, KICSTOR subunit 2, KICSTOR complex protein ITFG2, ... (4 entities in total)
• Functional Keywords: complex, lysosome, mtorc1, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 285987.10

Authors

Yang, A.,Liang, L. (deposition date: 2026-04-01, release date: 2026-08-26)

• Primary citation: Yang, A.,Liang, L.; Mechanistic insights into GATOR1 inhibition by GATOR2 and KICSTOR; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.81 Å)