24VT

Cryo-EM structure of the human KCNQ2/KCNQ3 heterotetramer (3:1 stoichiometry) with CLM142 (M2223 CLM142, with symmetry expansion)

This is a non-PDB format compatible entry.

Summary for 24VT

• Entry DOI: 10.2210/pdb24vt/pdb
• EMDB information: 69851
• Descriptor: Potassium voltage-gated channel subfamily KQT member 3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 2, ~{N}-(7-cyclopropyl-1-prop-2-ynyl-indazol-3-yl)-4-fluoranyl-benzamide, ... (5 entities in total)
• Functional Keywords: potassium channels, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 331615.44

Authors

Wang, Y.F.,Yang, H.,Qu, Y.N.,Shen, H.Z. (deposition date: 2026-03-22, release date: 2026-08-12)

• Primary citation: Wang, Y.,Yang, H.,Qu, Y.,Li, J.,Li, X.,Hou, W.,Wu, K.,Xie, G.,Wang, X.,Ye, Y.,Yang, H.,Shen, H.; Structural basis for heteromeric assembly and subthreshold activation of human M-channel; Vita, 2026; DOI: 10.15302/vita.2026.05.0032

Experimental method

ELECTRON MICROSCOPY (3.56 Å)