24VQ

Cryo-EM structure of the human KCNQ2/KCNQ3 heterotetramer (2:2 stoichiometry) in apo state (M2233 apo, with symmetry expansion)

Summary for 24VQ

Entry DOI	10.2210/pdb24vq/pdb
EMDB information	69848
Descriptor	Potassium voltage-gated channel subfamily KQT member 3, Green fluorescent protein,Potassium voltage-gated channel subfamily KQT member 2, (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(heptanoyloxy)methyl]ethyl octadecanoate, ... (4 entities in total)
Functional Keywords	potassium channels, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	314898.58
Authors	Wang, Y.F.,Yang, H.,Qu, Y.N.,Shen, H.Z. (deposition date: 2026-03-22, release date: 2026-08-12)
Primary citation	Wang, Y.,Yang, H.,Qu, Y.,Li, J.,Li, X.,Hou, W.,Wu, K.,Xie, G.,Wang, X.,Ye, Y.,Yang, H.,Shen, H. Structural basis for heteromeric assembly and subthreshold activation of human M-channel Vita, 2026 Cited by DOI: 10.15302/vita.2026.05.0032 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.48 Å)

Structure validation