24TI

Cryo-EM structure of the PCO371-bound GHRHR-Gs complex

Summary for 24TI

Entry DOI	10.2210/pdb24ti/pdb
EMDB information	69804
Descriptor	Growth hormone-releasing hormone receptor, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
Functional Keywords	ghrhr, pco371, membrane protein/immune system, membrane protein-immune system complex
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	173249.70
Authors	Wang, M.W.,Hang, K.N.,Qiu, Y.,Chen, X.Y.,Chen, Y.Y.,Huang, S.T.,Cong, Z.T.,Zhou, Q.T. (deposition date: 2026-03-19, release date: 2026-07-08)
Primary citation	Wang, M.W.,Hang, K.,Qiu, Y.,Chen, X.,Chen, Y.,Huang, S.,Cong, Z.,Zhou, Q. Structural adaptation associated with signaling preference at the human GHRHR. Protein Cell, 2026 Cited by PubMed: 41849435 DOI: 10.1093/procel/pwag016 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.88 Å)

Structure validation