24TB

Cryo-EM structure of the ligand-free (Apo) GHRHR-Gs complex

Summary for 24TB

Entry DOI	10.2210/pdb24tb/pdb
EMDB information	69803
Descriptor	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (4 entities in total)
Functional Keywords	gpcr, complex, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	158902.77
Authors	Wang, M.W.,Hang, K.N.,Qiu, Y.,Chen, X.Y.,Chen, Y.Y.,Cong, Z.T.,Zhou, Q.T. (deposition date: 2026-03-19, release date: 2026-07-08)
Primary citation	Wang, M.W.,Hang, K.,Qiu, Y.,Chen, X.,Chen, Y.,Huang, S.,Cong, Z.,Zhou, Q. Structural adaptation associated with signaling preference at the human GHRHR. Protein Cell, 2026 Cited by PubMed: 41849435 DOI: 10.1093/procel/pwag016 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.04 Å)

Structure validation