24HR

Human KRAS G12D (GDP-bound) in complex with macrocyclic peptide inhibitor AP6252

This is a non-PDB format compatible entry.

Summary for 24HR

• Entry DOI: 10.2210/pdb24hr/pdb
• Descriptor: Isoform 2B of GTPase KRas, AP6252, GUANOSINE-5'-DIPHOSPHATE, ... (7 entities in total)
• Functional Keywords: kras, macrocyclic peptide, oncology, signaling protein, signaling protein-inhibitor complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 90111.39

Authors

Yamano, T.,Chiyoda, A.,Fukami, T.A.,Tanada, M.,Irie, M.,Torizawa, T. (deposition date: 2026-03-04, release date: 2026-05-27)

• Primary citation: Chiyoda, A.,Matsuo, A.,Yamano, T.,Tanada, M.; Structure-Activity Relationship Analysis of Macrocyclic Peptide RAS Inhibitors: Spotlight on the Solvent-Exposed Region; Acs Med.Chem.Lett., 2026; DOI: 10.1021/acsmedchemlett.6c00122

Experimental method

X-RAY DIFFRACTION (2.07 Å)