23WO

Cryo-EM structure of the de novo designed metalloprotease DP221 E85Q mutant

Summary for 23WO

• Entry DOI: 10.2210/pdb23wo/pdb
• EMDB information: 69323
• Descriptor: DP221, Amyloid-beta protein 42, ZINC ION (3 entities in total)
• Functional Keywords: de novo designed metalloprotease, de novo protein
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 174856.68

Authors

Qu, Y.N.,Cao, L.X. (deposition date: 2026-02-23, release date: 2026-08-05)

• Primary citation: Qu, Y.,Wang, C.,Zhu, H.,Wang, Y.,Cao, L.; De novo design of metalloproteases for targeted amyloid-beta cleavage; Vita, 2026; DOI: 10.15302/vita.2026.07.0055

Experimental method

ELECTRON MICROSCOPY (3.5 Å)